The similarity of the clinical symptoms of acute respiratory viral infections (ARVI) creates difficulties for clinical diagnosis, which leads to the late appointment of specific antiviral therapy and increases the risk of complications. Objective of the research: to study the etiological picture of ARVI among hospitalized children in the epidemic season 2018–2019. to optimize antiviral therapy. Materials and methods: 378 patients from 1 month to 17 years old with various acute respiratory viral infections were examined, for the detection of pathogens method of real-time multiplex PCR was used. Results: the viral etiology of respiratory tract lesions was confirmed in 84,4% of the examined. Among ARVI, non-influenza pathogens were leading (60,2%), more often respiratory syncytial viruses (19,4%). Other pathogens (parainfluenza, adeno-, rino-, metapneumo-, corona- and bocaviruses) were considerably less common. In the structure of influenza, A/H1N1/ pdm09 viruses dominated (24,7%), less often A/H3N2/viruses (13,8%), type B viruses only in 2,5% of patients. In 10,7% of cases, virus-virus associations were detected, which included two (91,3%) and even three (8,7%) pathogens. Conclusion: rapid verification of the pathogen determines the rational choice of etiotropic agents (human recombinant interferon α-2b with antioxidants), allows to accelerate the regression of clinical symptoms and sanation from viral pathogens.
For citation: Timchenko V.N., Malinovskaya V.V., Baracina E.V., Pochinyaeva L.M., Shuvalov A.N., Sukhovetskaya V.F., Chernova T.M., Semenenko T.A.. The role of early etiological decoding of acute respiratory viral infections in antiviral therapy choice for children in a hospital setting. Pediatria n.a. G.N. Speransky. 2020; 99 (1): 100-106.